abstract：OBJECTIVE:Chlorobenzylidene malononitrile (CS) is the tear gas used by the police. The aim was to evaluate an amphoteric, hypertonic, and chelating rinsing solution in CS exposure. METHODS:The first (CS) group of six police officers was exposed to CS only. The second (preexposure) group of eight sprayed their faces wi...

journal_title：Human & experimental toxicology

authors： Brvar M

更新日期：2016-02-01 00:00:00

abstract：:The aim of this study was focused on investigating the possible protective effect of erdosteine against gamma radiation-induced renal lesions in male albino rats. Twenty-eight albino rats were divided into four equal groups as follows: control group, irradiated group (animals subjected to whole-body gamma irradiation ...

journal_title：Human & experimental toxicology

authors： Elkady AA,Ibrahim IM

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The present work aimed to investigate the relationship between occupational exposure to airborne molds, serum aflatoxin B1 (AFB1), and liver enzymes of workers handling wheat flour. METHODS:The study included 90 bakers, 100 flour milling workers, and 100 controls with no exposure to flour dust. Workplace asp...

journal_title：Human & experimental toxicology

authors： Saad-Hussein A,Taha MM,Fadl NN,Awad AH,Mahdy-Abdallah H,Moubarz G,Aziz H,El-Shamy KA

更新日期：2016-01-01 00:00:00

abstract：:A key aim of toxicology is the prevention of adverse effects due to toxic hazards. Therefore, the dissemination of toxicology research findings must confront two important challenges: one being the lack of information on the vast majority of potentially toxic industrial chemicals and the other being the strict criteri...

journal_title：Human & experimental toxicology

authors： Grandjean P

更新日期：2015-12-01 00:00:00

abstract：:Predictive toxicology plays a critical role in reducing the failure rate of new drugs in pharmaceutical research and development. Despite recent gains in our understanding of drug-induced toxicity, however, it is urgent that the utility and limitations of our current predictive tools be determined in order to identify...

journal_title：Human & experimental toxicology

authors： Naven RT,Louise-May S

更新日期：2015-12-01 00:00:00

abstract：:Levo-Carnitine (l-carnitine) is widely used in health and food. This study was to focus on the adverse effects of 8-week oral supplementation of l-carnitine (0.3 and 0.6 g/kg) in female and male Sprague Dawley rats. l-carnitine reduced body and fat weights, as well as serum, liver, and kidney lipid levels in rats. Sim...

journal_title：Human & experimental toxicology

authors： Liu L,Zhang DM,Wang MX,Fan CY,Zhou F,Wang SJ,Kong LD

更新日期：2015-11-01 00:00:00

abstract：:Prolonged zidovudine (AZT) treatment in HIV-infected and AIDS patients is shown to induce liver toxicity leading to complications. Therapeutic regimen that could encounter this adverse effect is unavailable and management of toxicity is often symptomatic or is limited to withdrawal of therapy. In the present investiga...

journal_title：Human & experimental toxicology

authors： Raghu R,Jesudas B,Bhavani G,Ezhilarasan D,Karthikeyan S

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:Calcium channel blockers (CCBs) were the most common agents associated with a significant morbidity and mortality rate. The main objective of this study was to examine the publication pattern related to CCBs poisoning at the global level using bibliometric analysis of articles published in SciVerse Scopus onlin...

journal_title：Human & experimental toxicology

authors： Zyoud SH,Al-Jabi SW,Sweileh WM,Waring WS

更新日期：2015-11-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is an endogenously produced gaseous messenger that participates in regulation of cardiovascular functions. This study evaluates the possible protective effect of H2S in cardiovascular dysfunction induced by cecal ligation and puncture (CLP) in rats. After 24 h of induction of CLP, heart rate (HR...

journal_title：Human & experimental toxicology

authors： Abdelrahman RS,El-Awady MS,Nader MA,Ammar EM

更新日期：2015-10-01 00:00:00

abstract：:The identification of biomarkers for toxicity prediction is crucial for drug development and safety evaluation. The selective and specific biomarkers for antihistamines-induced cardiotoxicity is not well identified yet. In order to evaluate the mechanism of the life-threatening effects caused by antihistamines, we use...

journal_title：Human & experimental toxicology

authors： Yun JS,Kim SY

更新日期：2015-08-01 00:00:00

abstract：:This study evaluated the protective potential of curcumin on the possible side effects of bortezomib (Bt) therapy on normal cells in mice. The mice were segregated into three groups (n = 10) that included normal control, Bt-treated, and Bt + curcumin-treated groups. The Bt treatment resulted in significant decrease in...

journal_title：Human & experimental toxicology

authors： Kumar RR,Malhotra A

更新日期：2015-07-01 00:00:00

abstract：:N-nitrosodimethylamine (NDMA) is a xenobiotic widespread in human environment capable of regulating the lifespan of immune cells. In this study, we examined the roles of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor 5 (DR5) complex and the Fas molecule in the induction of the extri...

journal_title：Human & experimental toxicology

authors： Iwaniuk A,Jabłońska E,Jabłoński J,Ratajczak-Wrona W,Garley M

更新日期：2015-06-01 00:00:00

abstract：:The present study was undertaken to investigate the effects of maternal lead (Pb) exposure on the expression of interleukin (IL) 1β, IL 6, and glial fibrillary acidic protein (GFAP) in hippocampus of mice offspring. Pb exposure initiated from the beginning of gestation to weaning. Lead acetate (PbAc) administered in d...

journal_title：Human & experimental toxicology

authors： Li N,Liu X,Zhang P,Qiao M,Li H,Li X,Zhang H,Yu Z

更新日期：2015-04-01 00:00:00

abstract：:In carbon monoxide (CO) poisoning, CO affects the oxygen-carrying capacity of the hemoglobin molecule. Nucleolar-organizing regions (NORs) are genetic loci on chromosomes that are composed of ribosomal DNA and proteins. NORs can be stained with silver. A total of 18 rats were exposed to CO in three different concentra...

journal_title：Human & experimental toxicology

authors： Çolakoğlu S,Saritas A,Eroz R,Oktay M,Yaykasli KO,Akoz A,Kaya E,Kandis H

更新日期：2015-01-01 00:00:00

abstract：:Pityriasis rosea (PR) is a common, acute, and self-limited inflammatory skin disease. The typical clinical presentation includes the appearance of a primary "herald" patch followed within days to weeks by the onset of secondary scaly skin eruptions distributed along the skin tension line in most cases. Although PR is ...

journal_title：Human & experimental toxicology

authors： Polat M,Uzun Ö,Örs I,Boran Ç

更新日期：2014-12-01 00:00:00

abstract：:Celecoxib has been shown to have antitumor effect in previous studies but the mechanisms are unclear. The effect of celecoxib on cytosolic Ca(2+) concentrations ([Ca(2+)]i) and viability in HA59T human hepatoma cells was explored. The Ca(2+)-sensitive fluorescent dye fura-2 was applied to measure [Ca(2+)]i. Celecoxib ...

journal_title：Human & experimental toxicology

authors： Cheng HH,Chou CT,Lu YC,Lu T,Chi CC,Tseng LL,Liu SI,Cheng JS,Kuo CC,Liang WZ,Jan CR

更新日期：2014-11-01 00:00:00

abstract：:Puerarin, a potent free radicals scavenger, has been demonstrated to have protective efficacy in oxidative damage induced by nephrotoxins. In the present study, the attenuating effect of puerarin (PU) on lead (Pb)-induced apoptosis and oxidative stress was investigated in cultured primary rat proximal tubular (rPT) ce...

journal_title：Human & experimental toxicology

authors： Liu G,Li Z,Wang J,Wang H,Wang Z,Wang L

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate, the cytotoxicity of orthodontic composites in vitro as a function of degree of conversion (DC) and the light curing units (LCU) employed on mouse fibroblast (L929). MATERIALS AND METHODS:Cured samples of the composites Light bond (Reliance Orthodontic Products, Itasca,...

journal_title：Human & experimental toxicology

authors： Cörekçi B,Irgın C,Halıcıoğlu K,Dursun S,Yavuz MZ

更新日期：2014-10-01 00:00:00

abstract：:Mercury, a heavy metal, is widespread and persistent in the environment and has been elucidated as a possible risk factor in cardiovascular diseases. Mercury has been reported to selectively impair the nitric oxide (NO) pathway in the vascular endothelium as a consequence of oxidative stress. Conversely, mercury per s...

journal_title：Human & experimental toxicology

authors： Omanwar S,Saidullah B,Ravi K,Fahim M

更新日期：2014-09-01 00:00:00

abstract：:The mechanism of doxorubicin (DOX)-induced cardiotoxicity remains controversial. Wistar rats (n = 66) received DOX injections intraperitoneally and were randomly assigned to 2 experimental protocols: (1) rats were killed before (-24 h, n = 8) and 24 h after (+24 h, n = 8) a single dose of DOX (4 mg/kg body weight) to ...

journal_title：Human & experimental toxicology

authors： Segredo MP,Salvadori DM,Rocha NS,Moretto FC,Correa CR,Camargo EA,de Almeida DC,Reis RA,Freire CM,Braz MG,Tang G,Matsubara LS,Matsubara BB,Yeum KJ,Ferreira AL

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Chronic obstructive pulmonary disease (COPD) due to sulfur mustard (SM), known as mustard lung, is an important late pulmonary complication of SM poisoning. Due to the possible role of systemic inflammation in mustard lung, we evaluated the serum levels of adiponectin and leptin in these patients. MATERIA...

journal_title：Human & experimental toxicology

authors： Rokni Yazdi H,Lari SM,Attaran D,Ayatollahi H,Mohsenizadeh A

更新日期：2014-06-01 00:00:00

abstract：:Accumulating evidence has shown that ethanol-induced iron overload plays a crucial role in the development and progression of alcoholic liver disease. We designed the present study to investigate the potential protective effect of quercetin, a naturally occurring iron-chelating antioxidant on alcoholic iron overload a...

journal_title：Human & experimental toxicology

authors： Li Y,Deng Y,Tang Y,Yu H,Gao C,Liu L,Liu L,Yao P

更新日期：2014-05-01 00:00:00

abstract：:The isolated and identified triterpenoid, 1-hydroxytetratriacontane-4-one (C34H68O2), obtained from the methanolic leaf extract of Leucas aspera Linn. was explored for the first time for antisnake venom activity. The plant (L. aspera Linn.) extract significantly antagonized the spectacled cobra (Naja naja naja) venom ...

journal_title：Human & experimental toxicology

authors： Venkatesan C,Sarathi M,Balasubramanian G,Thomas J,Balachander V,Babu VS,Bilal SM,Majeed SA,Madan N,Raj NS,Vimal S,Nambi KS,Hameed AS

更新日期：2014-04-01 00:00:00

abstract：:The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, was associated with the alteration of hippocampal short-term potentiation (STP) and long-term potentiation (LTP) and to discuss the potential underlying mechanism. Young adult offspring rats ...

journal_title：Human & experimental toxicology

authors： Han G,An L,Yang B,Si L,Zhang T

更新日期：2014-02-01 00:00:00

abstract：:Pesticides are used in agriculture to protect crops from insects-pests. Most of the field workers of North Indian population are exposed to commonly used insecticides. In the present study, pesticides induced oxidative stress as well as alterations in the level of acetylcholinesterase (AChE) in a total of 70 male heal...

journal_title：Human & experimental toxicology

authors： Sharma RK,Upadhyay G,Siddiqi NJ,Sharma B

更新日期：2013-11-01 00:00:00

abstract：:Dimerized translationally controlled tumor protein (dTCTP) plays a role in allergic diseases. A 7-mer peptide, dimerized translationally binding protein 2 (dTBP2), binds to dTCTP and inhibits dTCTP, suggesting that the 7-mer peptide may have therapeutic potential. We assessed the safety of dTBP2 by examining its cytot...

journal_title：Human & experimental toxicology

authors： Kim M,Jin YB,Lee K,Lee YS

更新日期：2013-11-01 00:00:00

abstract：:Sepsis, often initiated by an infection, is a state of disrupted inflammatory homeostasis. There is increasing evidence that oxidative stress has an important role in the development of sepsis-induced multiorgan failure. Resveratrol (RV) is a polyphenolic compound found in the skin of red fruits, such as mulberries an...

journal_title：Human & experimental toxicology

authors： Aydin S,Bacanli M,Taner G,Şahin T,Başaran AA,Başaran N

更新日期：2013-10-01 00:00:00

abstract：:Recent studies have proposed the use of low concentrations of phytochemicals and combinations of phytochemicals in chemoprevention to reduce cytotoxicity and simulate normal ingestion through diet. The purpose of the present study was to evaluate whether the DNA damage, chromosome instability, and oxidative stress ind...

journal_title：Human & experimental toxicology

authors： Serpeloni JM,Almeida MR,Mercadante AZ,Bianchi ML,Antunes LM

更新日期：2013-08-01 00:00:00

abstract：:Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The (99m)Technetium-pertechnetate thyroid scan showed irregular up...

journal_title：Human & experimental toxicology

authors： Kim SK,Lee SM,Yoo SS,Hahm JR,Jung JH,Kim HS,Kim S,Chung SI,Jung TS

更新日期：2013-08-01 00:00:00

abstract：:Serrapeptase (SP) and nattokinase (NK) are proteolytic enzymes belonging to serine proteases. In this study, we hypothesized that SP and NK could modulate certain factors that are associated with Alzheimer's disease (AD) pathophysiology in the experimental model. Oral administration of aluminium chloride (AlCl3) in a ...

journal_title：Human & experimental toxicology

authors： Fadl NN,Ahmed HH,Booles HF,Sayed AH

更新日期：2013-07-01 00:00:00

abstract：:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...

journal_title：Human & experimental toxicology

authors： El-Ebiary AA,Abuelfadl AA,Sarhan NI,Othman MM

更新日期：2013-06-01 00:00:00

abstract：:Epichlorohydrin (ECH) is an antifertility agent that acts both as an epididymal toxicant and an agent capable of directly affecting sperm motility. This study identified the time course of apoptotic cell death in rat epididymides after ECH treatment. Rats were administrated with a single oral dose of ECH (50 mg/kg). E...

journal_title：Human & experimental toxicology

authors： Lee IC,Kim KH,Kim SH,Baek HS,Moon C,Kim SH,Yun WK,Nam KH,Kim HC,Kim JC

更新日期：2013-06-01 00:00:00

abstract：:The aim of this study was to compare the number of inactivated-influenza vaccine-related spontaneous abortion and stillbirth (SB) reports in the Vaccine Adverse Event Reporting System (VAERS) database during three consecutive flu seasons beginning 2008/2009 and assess the relative fetal death reports associated with t...

journal_title：Human & experimental toxicology

authors： Goldman GS

更新日期：2013-05-01 00:00:00

abstract：:The present study was designed to evaluate the cardioprotective potential of lycopene (LCP) against isoproterenol (ISP)-induced myocardial infarction (MI), by assessing hemodynamic, biochemical and histopathological parameters. Wistar male albino rats were orally administered with LCP (0.5, 1.0 and 1.5 mg/kg) or with ...

journal_title：Human & experimental toxicology

authors： Ojha S,Goyal S,Sharma C,Arora S,Kumari S,Arya DS

更新日期：2013-05-01 00:00:00

abstract：:The modulating effect of peroxisome proliferator-activated receptor α ligand on haemodynamic effects of phenylepherine (PE), angiotensin II (AII), endothelin 1 (ET1), acetylcholine (Ach), sodium nitroprusside (SNP) and isoproterenol (ISO) were evaluated in glycerol-induced acute kidney injury in rats. The effect of PE...

journal_title：Human & experimental toxicology

authors： Adedapo AA,Oyekan AO

更新日期：2013-03-01 00:00:00

abstract：:Oxidative stress has an important role in the pathophysiology of many occupational diseases. In this controlled exposure study, the intensity of oxidative stress biomarkers was assessed in the workers of natural sweet and sour gas refineries (SwGR and SoGR, respectively) and compared with controls. In addition, the ro...

journal_title：Human & experimental toxicology

authors： Mandegary A,Sezavar M,Saeedi A,Amirheidari B,Naghibi B

更新日期：2012-12-01 00:00:00

abstract：:In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...

journal_title：Human & experimental toxicology

authors： Kaymak C,Kadioglu E,Coskun E,Basar H,Basar M

更新日期：2012-12-01 00:00:00

abstract：:Organophosphate-induced delayed neuropathy (OPIDN) is a progressive neuropathic disorder that manifests in days to weeks following exposure to an acute dose of organophosphates. The precise mechanism involved in the development of OPIDN is not clear as it develops after many days of the cessation of cholinergic crisis...

journal_title：Human & experimental toxicology

authors： Masoud A,Sandhir R

更新日期：2012-12-01 00:00:00

abstract：:Safrole, a component of piper betle inflorescence, is a documented rodent hepatocarcinogen and inhibits bactericidal activity and the release of superoxide anion (O(2-)) by polymorphonuclear leukocytes (PMNs). In the present study, we investigated the effects of safrole on immune responses, including natural killer (N...

journal_title：Human & experimental toxicology

authors： Fan MJ,Lin SY,Yu CC,Tang NY,Ho HC,Chung HK,Yang JS,Huang YP,Ip SW,Chung JG

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Pesticide poisoning stands as a major public health issue worldwide. The objective of this study was to examine the epidemiologic characteristics of pesticide-related hospitalizations in South Korea. METHODS:Data from the Korea National Hospital Discharge Survey were analyzed to describe the epidemiologic c...

journal_title：Human & experimental toxicology

authors： Kim HJ,Cha ES,Ko Y,Kim J,Kim SD,Lee WJ

更新日期：2012-08-01 00:00:00